Molecules

Methyl mercapturate synthesis: an efficient, convenient and simple method

B Cossec, F Cosnier, M Burgart

Index: Cossec, Benoit; Cosnier, Frederic; Burgart, Manuella Molecules, 2008 , vol. 13, # 10 p. 2394 - 2407

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Citation Number: 8

Abstract

Abstract: A safe and simple method for methyl S-arylmercapturate synthesis is described. Thirteen such compounds, to be used afterwards in metabolism studies, have been obtained with yields ranging from 71 to 99.6%. These compounds were obtained using a sulfa- Michael addition and synthesized by adding the corresponding thiophenols to a mixture composed of methyl 2-acetamidoacrylate (MAA), potassium carbonate and a phase ...