Synthesis of serine analogues to be used as modified phospho acceptor sites in substrates of protein kinase C

HJG Broxterman, RMJ Liskamp

Index: Broxterman, H. J. G.; Liskamp, R. M. J. Recueil des Travaux Chimiques des Pays-Bas, 1991 , vol. 110, # 2 p. 46 - 52

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Citation Number: 4

Abstract

Abstract Serine and threonine analogues (compounds 2-6) are readily accessible by reaction of the anion of N, N-dibenzylglycine ethyl ester (1) with an appropriate carbonyl compound. These analogues will be incorporated into Protein Kinase C (PKC) substrates. The serine aldehyde derivative 7 was used for the preparation of the corresponding diethyl acetal 9. This compound was the starting material in the synthesis of the suicide precursor ...