Piperazine derivatives of 2-furanyl [1, 2, 4] triazolo [1, 5-a][1, 3, 5] triazine have recently been demonstrated to be potent and selective adenosine A2a receptor antagonists with oral activity in rodent models of Parkinson's disease. We have replaced the piperazinyl group with a variety of linear, monocyclic, and bicyclic diamines. Of these diamines,(R)-2- (aminomethyl) pyrrolidine is a particularly potent and selective replacement for the ...
