S-3578, A New Broad Spectrum Parenteral Cephalosporin Exhibiting Potent Activity Against both Methicillin-resistant Staphylococcus aureus (MRSA) and …

H Yoshizawa, H Itani, K Ishikura, T Irie, K Yokoo…

Index: Yoshizawa, Hidenori; Itani, Hikaru; Ishikura, Koji; Irie, Tadashi; Yokoo, Katsuki; Kubota, Tadatoshi; Minami, Kyoji; Iwaki, Tsutomu; Miwa, Hideaki; Nishitani, Yasuhiro Journal of Antibiotics, 2002 , vol. 55, # 11 p. 975 - 992

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Citation Number: 23

Abstract

A series of 7-aminothiadiazolylcephalosporins having a 1-(substituted)-1H-imidazo [4, 5-b] pyridinium group at the C-3'position of the cephem nucleus were synthesized and evaluated for in vitro antibacterial activities. Among the cephalosporins prepared in this study, 7β-[2-(5- amino-1, 2, 4-thiadiazol-3-yl)-2 (Z)-ethoxyiminoacetamido]-3-[1-(3-methylaminopropyl)-1H- imidazo [4, 5-b] pyridinium-4-yl] methyl-3-cephem-4-carboxylate sulfate (S-3578) showed ...