Organic Letters 2011-10-07

Nucleophilic dearomatization of chloromethyl naphthalene derivatives via η3-benzylpalladium intermediates: a new strategy for catalytic dearomatization.

Bo Peng, Sheng Zhang, Xiaoqiang Yu, Xiujuan Feng, Ming Bao

Index: Org. Lett. 13(19) , 5402-5, (2011)

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Abstract

Palladium-catalyzed nucleophilic dearomatization of chloromethyl naphthalene derivatives to produce ortho- or para-substituted carbocycles in satisfactory to excellent yields has been developed. The unprecedented dearomatization reactions proceeded smoothly under mild conditions via η(3)-benzylpalladium intermediates.© 2011 American Chemical Society