Toxicology Letters 1981-01-01

In vitro transformation of hamster embryo cells by 3-(N-salicyloyl)amino-1,2,4-triazole.

K Inoue, Y Katoh, S Takayama

Index: Toxicol. Lett. 7(3) , 211-5, (1981)

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Abstract

The in vitro carcinogenic activities of 3-(N-salicyloyl)amino-1,2,4-triazole (SAT) and its two components, 3-amino-1,2,4-triazole and phenyl salicylate were examined in a transformation assay with cryopreserved hamster embryo cells. SAT induced morphological transformation at certain doses between 10 microgram/ml and 100 microgram/ml in each of 5 repeated experiments, but gave a negative result in the Salmonella mutation assay. 3-Amino-1,2,4-triazole also induced transformation in 3 repeated experiments. Phenyl salicylate did not induce transformation at any of the doses tested in 3 consecutive experiments.