Synthesis of Differently Disubstituted 2, 2′??Bipyridines by a Modified Negishi Cross??Coupling Reaction

…, M Hapke, H Staats, J Bunzen

Index: Luetzen, Arne; Hapke, Marko; Staats, Holger; Bunzen, Jens European Journal of Organic Chemistry, 2003 , # 20 p. 3948 - 3957

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Citation Number: 27

Abstract

Abstract A general practical approach to a number of differently disubstituted 2, 2′- bipyridines from substituted 2-bromo-and 2-chloropyridines by application of modified Negishi cross-coupling conditions has been developed. These 2, 2′-bipyridines carry versatile functional groups that can be elaborated further, as demonstrated for some examples.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)