A series of 1, 3, 4-oxadiazole derivatives derived from 4-methoxysalicylic acid or 4- methylsalicylic acid (6a–6z) have been first synthesized for their potential immunosuppressive activity. Among them, compound 6z displayed the most potent biological activity against lymph node cells (inhibition= 38.76% for lymph node cells and IC50= 0.31 μM for PI3Kγ). The preliminary mechanism of compound 6z inhibition effects ...
