Journal of Antibiotics 2007-03-01

Selective and potent in vitro antimalarial activities found in four microbial metabolites.

Hideaki Ui, Aki Ishiyama, Hitomi Sekiguchi, Miyuki Namatame, Aki Nishihara, Yoko Takahashi, Kazuro Shiomi, Kazuhiko Otoguro, Satoshi Omura

Index: J. Antibiot. 60(3) , 220-2, (2007)

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Abstract

Antimalarial activities have been identified in four microbial metabolites through a screening programme of existing compounds in the Kitasato Institute chemical library. Hedamycin showed selective and potent activity against both drug-resistant and drug-sensitive strains of Plasmodium falciparum. Simaomicin alpha exhibited remarkably strong antimalarial activity, although its activity against a drug-resistant strain was weaker than that against a drug-sensitive strain. The antimalarial effects of triacsins C and D are also reported.