The Discovery of 4-{1-[({2, 5-Dimethyl-4-[4-(trifluoromethyl) benzyl]-3-thienyl} carbonyl) amino] cyclopropyl} benzoic Acid (MK-2894), A Potent and Selective …

M Blouin, Y Han, J Burch, J Farand…

Index: Journal of Medicinal Chemistry, , vol. 53, # 5 p. 2227 - 2238

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Citation Number: 13

Abstract

... Journal of Medicinal ... Department of Medicinal Chemistry. § Department of ... are not clearly understood, although it is speculated that inhibition of prostacyclin biosynthesis may cause the prothrombotic and hypertensive effects.(4) Therefore, there is a vast unmet medical need to ...