Chemical Communications

Unexpected selectivity in ruthenium-catalyzed hydrosilylation of primary amides: synthesis of secondary amines

B Li, JB Sortais, C Darcel

Index: Li, Bin; Sortais, Jean-Baptiste; Darcel, Christophe Chemical Communications, 2013 , vol. 49, # 35 p. 3691 - 3693

Full Text: HTML

Citation Number: 25

Abstract

Selective ruthenium-catalyzed reductive coupling of primary amides under hydrosilylation conditions is achieved using an one pot procedure. Using 3 equiv. of phenylsilane and [RuCl2 (mesitylene)] 2 (1–2 mol%) as the catalyst at 100° C under neat conditions, secondary symmetric amines were obtained in good yields and with high chemoselectivities.