CardioVascular and Interventional Radiology 2013-02-01

Incompatibility of contrast medium and trisodium citrate.

Christian Delcour, Guy Bruninx

Index: Cardiovasc. Intervent. Radiol. 36(1) , 237-8, (2013)

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Abstract

To test the compatibility of trisodium citrate, a catheter lock solution, with iodinated contrast medium.Iohexol, iobitridol, iodixanol, ioxaglate, ioxithalamate, iomeprol, and iopromide were tested. In all tests, 2 ml of contrast medium were mixed with 2 ml of trisodium citrate solution.Iodixanol and ioxaglate provoked a highly viscous gluelike precipitation when mixed with trisodium citrate. A brief transient precipitate was observed with iohexol, iomeprol, and ioxithalamate. Permanent precipitation occurred with iobitridol and iopromide.One must be aware of the potential for precipitation when contrast medium is mixed with trisodium citrate solution. Before trisodium citrate solution is injected, the catheter should be thoroughly flushed with saline if a contrast medium has previously been injected through it.