Pacing and Clinical Electrophysiology 2007-08-01

QT Interval prolongation and torsades de pointes due to a coadministration of ciprofloxacin and azimilide in a patient with implantable cardioverter-defibrillator.

Jarosław Kaźmierczak, Małgorzata Peregud-Pogorzelska, Ryszard Rzeuski

Index: Pacing Clin. Electrophysiol. 30(8) , 1043-6, (2007)

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Abstract

The presented case report describes a male patient with an implanted cardioverter-defibrillator (ICD) in whom a coadministration of ciprofloxacin and azimilide caused QT interval prolongation and multiple episodes of torsades de pointes (TdP) followed by ICD shocks (arrhythmic storm). The case highlights a not described drug interaction between azimilide and ciprofloxacin, which is believed to be the safest member of fluoroquinolones class.