Chemical Communications 2015-10-21

Electrochemical aptamer scaffold biosensors for detection of botulism and ricin toxins.

Lisa Fetter, Jonathan Richards, Jessica Daniel, Laura Roon, Teisha J Rowland, Andrew J Bonham

Index: Chem. Commun. (Camb.) 51(82) , 15137-40, (2015)

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Abstract

Protein toxins present considerable health risks, but detection often requires laborious analysis. Here, we developed electrochemical aptamer biosensors for ricin and botulinum neurotoxins, which display robust and specific signal at nanomolar concentrations and function in dilute serum. These biosensors may aid future efforts for the rapid diagnosis of toxins.