Nucleosides & nucleotides 1998-08-01

Synthesis of 1-(beta-D-glycopyranosyl)-3-deazapyrimidines from 2-hydroxy and 2-mercaptopyridines.

A M Attia, G H Elgemeie, I S Alnaimi

Index: Nucleosides Nucleotides 17(8) , 1355-63, (1998)

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Abstract

The synthesis of new 4- and 5-substituted-3-cyanopyridine nucleosides has been performed by reacting the silylated pyridines and penta-omicron-acetyl-alpha -D-glycopyranose in dichloroethane in the presence of SnCl4. The free nucleosides were tested for their potential activity against HIV and different types of tumor.