Cephalosporina with new catechol substituents at C-3'have been synthesized, including novel compounds with (2-3'carbon-carbon bonds. Many of these compounds have high potency against Gram-negative bacteria, in particular against resistant strains like Pseudomonos aeruginosa. Structure-activity relationships are discussed in tarme of their dependence on the pK, of the C-3'catechol and ale0 in terms of steric and conformational ...
