Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2012-08-30

Allethrin-induced genotoxicity and oxidative stress in Swiss albino mice

Amit Kumar Srivastava, Pramod Kumar Srivastava, Abdulaziz A. Al-Khedhairy, Javed Musarrat, Yogeshwer Shukla, Amit Kumar Srivastava, Pramod Kumar Srivastava, Abdulaziz A. Al-Khedhairy, Javed Musarrat, Yogeshwer Shukla, Amit Kumar Srivastava, Pramod Kumar Srivastava, Abdulaziz A. Al-Khedhairy, Javed Musarrat, Yogeshwer Shukla

Index: Mutat. Res. 747(1) , 22-8, (2012)

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Abstract

Highlights ► Allethrin has genotoxic potential in Swiss albino mice bone marrow cells. ► Allethrin induces significant oxidative stress in Swiss albino mice. ► Exposure of allethrin to Swiss albino mice caused upregulation of all four DNA damage responsive genes/proteins (p53, p21, GADD45α, and MDM2) in liver.