Hydroxycoumarin derivatives: Novel and potent α-glucosidase inhibitors

Q Shen, J Shao, Q Peng, W Zhang, L Ma…

Index: Shen, Qiong; Shao, Jialiang; Peng, Quan; Zhang, Wanjin; Ma, Lin; Chan, Albert S. C.; Gu, Lianquan Journal of Medicinal Chemistry, 2010 , vol. 53, # 23 p. 8252 - 8259

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Citation Number: 36

Abstract

A novel class of hydroxycoumarin derivatives were found to be potent α-glucosidase inhibitors. Their syntheses were reported and the structure− activity relationship was established. Kinetic enzymatic assays indicated that compound 10 was a slow-binding and noncompetitive inhibitor with a K i value of 589 nM, while compound 11 was a competitive inhibitor with a K i value of 4.810 μM. Among all hydroxycoumarin derivatives studied, ...