Thiourea and thiosemicarbazide derivatives structurally related to hexestrol: synthesis and anticancer and other pharmacological properties

…, NH Eshba, FM Sharabi, TT Daabees

Index: Omar; Farghaly; Hazzai; Eshba; Sharabi; Daabees Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 9 p. 1075 - 1079

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Citation Number: 9

Abstract

Abstract Two novel series of thio compounds bearing internal structural modifications of hexestrol were synthesized as potential anticancer agents. The first contains several N- substituted thiourea functions, and the second contains various N 4-substituted-3- thiosemicarbazide moieties in place of one α-ethyl group of hexestrol dimethyl ether. The products showed no antileukemic activity in the P-388 lymphocytic leukemia system and ...