Biotechnology Letters 2011-08-01

Industrial production of fructooligosaccharides by immobilized cells of Aureobasidium pullulans in a packed bed reactor.

K H Jung, S H Bang, T K Oh, H J Park

Index: Biotechnol. Lett. 33(8) , 1621-4, (2011)

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Abstract

Continuous production of fructooligosaccharides (FOS) by Aureobasidium pullulans immobilized on calcium alginate beads with a packed bed was investigated at a plant scale reactor. Optimum conditions were with 770 g sucrose/l, being fed at 200 l/h at 50°C which gave a productivity of 180 g FOS/l h. Initial activity was maintained for more than 100 days. The reactor was successfully scaled up to a production scale of 1.2 m(3).