Antimicrobial Agents and Chemotherapy 2008-12-01

Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs.

Bogdana Krivogorsky, Peter Grundt, Robert Yolken, Lorraine Jones-Brando

Index: Antimicrob. Agents Chemother. 52(12) , 4466-9, (2008)

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Abstract

New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3'-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.