European Journal of Medicinal Chemistry 2006-07-01

Synthesis and in vitro antibacterial activity of novel heterocyclic derivatives of 18-nor-equilenin.

A V Karnik, N J Malviya, A M Kulkarni, B L Jadhav

Index: Eur. J. Med. Chem. 41(7) , 891-5, (2006)

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Abstract

Syntheses of novel heterocyclic derivatives of 18-nor-equilenin, namely, (12H-11-oxa-17-thia-15-aza-cyclopenta[a]phenanthrene-16-yl)-hydrazine (4a/b) and its fused [1,2,4]triazolo derivatives6H-5-oxa-7-thia-8,9,10a-triaza-pentaleno[4,5-a]phenanthrene (5a/b), 10-methyl-6H-5-oxa-7-thia-8,9,10a-triaza-pentaleno[4,5-a]phenanthrene (6a/b) and tetrazolo derivatives 1-substituted-6H-5-oxa-7-thia-8,9,10,10a-tetraaza-pentaleno[4,5-a]phenanthrene (7a/b) along with their antibacterial activities are reported.