Beilstein Journal of Organic Chemistry 2012-01-01

Parallel solid-phase synthesis of diaryltriazoles.

Matthias Wrobel, Jeffrey Aubé, Burkhard König

Index: Beilstein J. Org. Chem. 8 , 1027-36, (2012)

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Abstract

A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide mimics and have therefore the potential to act as selective inhibitors for protein-protein interactions.