FEBS Letters 2013-11-15

Activation of the yeast cell wall integrity MAPK pathway by zymolyase depends on protease and glucanase activities and requires the mucin-like protein Hkr1 but not Msb2

José M. Rodríguez-Peña, Sonia Díez-Muñiz, Clara Bermejo, César Nombela, Javier Arroyo

Index: FEBS Lett. 587(22) , 3675-80, (2013)

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Abstract

• The main cell-wall digesting enzymes of zymolyase were individually inhibited. • β-1,3-Glucanase and protease activities are required for CWI MAPK pathway activation. • Hkr1 mucin is essential for signaling cell-wall damage caused by zymolyase in yeast.