Abstract Reaction of 3-acetyl-4, 6-dimethyl-2-(1H) pyridone (9a) with phosphoryl chloride gives 2-chloro-3-ethynyl-4, 6-dimethylpyridine (10a). 3-Acetyl-4-hydroxy-6-methyl-2 (1H) pyridone (14a) and 3-acetyl-2, 6-dimethyl-4-(1H)-pyridone (21) undergoes similar reaction to give the corresponding ethynyl (16 and 23) and chlorovinyl (15 and 22) pyridines, respectively. The chlorination of 3-acetylpyridine and pyrimidine derivatives is further ...
