Synthesis and in vitro antitubercular activity of alkylaminotetrahydrocarbazoles

…, TV Akalaeva, OY Amel'kin, AI Bokanov…

Index: Filitis, L. N.; Akalaeva, T. V.; Amel'kin, O. Yu.; Bokanov, A. I.; Ivanov, P. Yu.; Shvedov, V. I. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 10 p. 780 - 785 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 10 p. 1217 - 1222

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Abstract

Sodium borohydride was found to be the most convenient reducing agent for converting the iminocarbazoles XIV-XXIV to the amines III-XIII. In an alcohol medium at 20~ the process proceeded with the complete conversion of the imino compounds (TLC control method). The reduction of the imine XXV by sodium borohydride has been previously described [i]. LiAIH~, a more vigorous reducing agent; converted the XXV imine to ethylaminocarbazole II, ie, ...