Carbohydrate Research 1977-02-01

Chemical modification of neamine.

T Suami, S Nishiyama, Y Ishikawa, S Katsura

Index: Oncogene 21(28) , 4462-70, (2002)

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Abstract

The aminocyclitol antibiotic neamine has been modified chemically by removing one or two hydroxyl groups from the 2-deoxystreptamine moiety to give 5- and 6- deoxyneamines (5 and 10), as well as 5,6-dideoxyneamine (15). Their antimicrobial activities were determined against several microorganisms, including kanamycin-resistant strains.