Inhibition of phenylethanolamine N-methyl transferase by benzylamines. 1. Structure-activity relations

RW Fuller, BB Molloy, WA Day, BW Roush…

Index: Fuller; Molloy; Day; Roush; Marsh Journal of medicinal chemistry, 1973 , vol. 16, # 2 p. 101 - 106

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Citation Number: 44

Abstract

D-threo-(1R, 2R)-1-p-Nitrophenyl-2-amino-1, 3-propanediol IXXVII): CD (c 1.13. Cuura A)[e 1~~~+ 1 7 5,[8] 650+ 190,[81sao 0, iei,,, o~ reisso-sos*; cD (~ 0. 1 1 3,~ upra~)-3035*; CD (c 0.023, Cupra A)[61z85-4340,[01275-2890. amido-1, 3-propanedioI (XXVIII). This material was incompletely soluble in Cupra A. It gave a broad negative band at about 650 nm and a strong positive peak at 280 nm: CD (c 0.479, methanol) I~ 13so0,[e] 325+ 170,[eI3,,+ 97*; ...