Journal of Dermatological Treatment 2010-11-01

An occlusive dressing containing betamethasone valerate 0.1% for the treatment of prurigo nodularis.

Rosita Saraceno, Andrea Chiricozzi, Steven Paul Nisticò, Sergio Tiberti, Sergio Chimenti

Index: J. Dermatolog. Treat. 21(6) , 363-6, (2010)

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Abstract

Prurigo nodularis is a distressing condition characterized by the presence of multiple nodules associated with intense pruritus.To assess the clinical efficacy and safety of betamethasone valerate 0.1% tape and a moisturizing itch-relief cream in prurigo nodularis.Twelve patients were enrolled in this pilot comparison of betamethasone valerate 0.1% tape versus a moisturizing itch-relief cream containing feverfew. The study period was 4 weeks. Clinical evaluation was performed weekly.Eleven subjects completed the 4 weeks of therapy. The mean visual analogue scale (VAS) for pruritus at baseline was 8.75 for both sides of the body. The side treated with betamethasone valerate 0.1% tape showed a higher clinical response (VAS score at week 4: 3.9; p < 0.005) compared with the side treated with moisturizing itch-relief cream (VAS score at week 4: 5.6; p < 0.005).Both treatments were effective. However, the occlusive dressing enhanced the efficacy of the treatment, preventing scratching.