Chemical Communications 2012-12-14

Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function.

Adam G Newman, Anna L Vagstad, Katherine Belecki, Jonathan R Scheerer, Craig A Townsend

Index: Chem. Commun. (Camb.) 48(96) , 11772-4, (2012)

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Abstract

The polyketide synthase CTB1 is demonstrated to catalyze pyrone formation thereby expanding the known biosynthetic repertoire of thioesterase domains in iterative, non-reducing polyketide synthases.