Journal of Chromatography B 2011-11-15

Preparation of high purity biphenyl cyclooctene lignans from Schisandra extract by ion exchange resin catalytic transformation combined with macroporous resin separation.

Chun-hui Ma, Ting-ting Liu, Lei Yang, Yuan-gang Zu, Feng-jian Yang, Chun-jian Zhao, Lin Zhang, Zhong-hua Zhang, Chun-hui Ma, Ting-ting Liu, Lei Yang, Yuan-gang Zu, Feng-jian Yang, Chun-jian Zhao, Lin Zhang, Zhong-hua Zhang

Index: J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(30) , 3444-51, (2011)

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Abstract

In this study, ester-bond biphenyl cyclooctene lignans were efficiently hydrolytically degraded into free biphenyl cyclooctene lignans by ion exchange resin transformation and simultaneous removal of impurities by macroporous resin. The OH-type strongly basic anion exchange resin 201×7 was the best one, and the dynamic hydrolysis efficiency was 146.7±5.0%. HPD5000 macroporous resin, which offered higher adsorption and desorption capacities and faster adsorption than other resins. The purity of free biphenyl cyclooctene lignans in the product increased from 5.14±0.24% to 79.67±0.0.67%. After dynamic catalytic transformation by 201×7 resin combined with purification of HPD5000 resin, the yield and the purity of free biphenyl cyclooctene lignans in the product were 132.1±4.7% and 80.91±3.53%, respectively.Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.