The Application of Dialkylphosphite as the Amino Protection Reagent in Organic Synthesis

YF Zhao, GJ Ji, SK Xi, HG Tang, AT Song…

Index: Zhao, Yu-Fen; Ji, Gai-Jiao; Xi, She-Kang; Tang, Hue-Gong; Song, Ai-Teng; Wei, Shou-Zuo Phosphorus and Sulfur and the Related Elements, 1983 , vol. 18, p. 155 - 158

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Citation Number: 6

Abstract

Abstract The acid hydrolysis of N-phenyl-N-dialkyl-phosphoramidates was studied by HPLC, the N-phenyl-N-diisopropylphosphoramidate has half life 53 min in 6N HCl at 50° C. The PN bonds of these phosphoryl derivatives also show a relative stability in organic and Lewis acids.