Polish Journal of Pharmacology 2000-01-01

Combined treatment with NMDA antagonist, CGP 37849, and sigma receptor agonists, SA4503 or DTG, decreases the neuroleptic-induced catalepsy in rats.

G Skuza

Index: Pol. J. Pharmacol. 52(4) , 313-6, (2000)

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Abstract

The obtained results indicate that joint administration of CGP 37849, a competitive NMDA receptor antagonist, and SA4503, a sigma1 (sigma1) receptor agonist or DTG, sigma 1/2 receptor agonist, evoked anticataleptic effect at doses which were ineffective when each of the compounds was given alone.