Organic & Biomolecular Chemistry 2008-01-07

Phenothiazine as a redox-active DNA base substitute: comparison with phenothiazine-modified uridine.

Clemens Wagner, Hans-Achim Wagenknecht

Index: Org. Biomol. Chem. 6(1) , 48-50, (2008)

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Abstract

Phenothiazine can be incorporated as a redox-active probe into DNA in two conceptually different ways: the non-nucleosidic DNA base surrogate exhibits similar properties to 10-methylphenothiazine but with no preferential base-pairing properties, whereas the phenothiazine-modified uridine has different optical and electrochemical properties, but exhibits preferred Watson-Crick base pairing with adenine.