Efficient H/D Exchange Reactions of Alkyl??Substituted Benzene Derivatives by Means of the Pd/C–H2–D2O System

…, T Maegawa, Y Monguchi, H Sajiki

Index: Esaki, Hiroyoshi; Aoki, Fumiyo; Umemura, Miho; Kato, Masatsugu; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao Chemistry - A European Journal, 2007 , vol. 13, # 14 p. 4052 - 4063

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Citation Number: 54

Abstract

Abstract A method for efficient and extensive H/D exchange of substituted benzene derivatives which is catalyzed by heterogeneous Pd/C in D 2 O as a deuterium source under hydrogen atmosphere is described. Multideuterium incorporation into unactivated linear or branched alkyl chains that bear a carboxyl, hydroxyl, ether, ester, or amide moiety and are connected with a benzene ring was achieved by using the Pd/C–H 2–D 2 O system. The ...