Journal of the American Chemical Society 2012-06-20

Palladium-catalyzed oxidative carbonylation of benzylic C-H bonds via nondirected C(sp3)-H activation.

Pan Xie, Yinjun Xie, Bo Qian, Han Zhou, Chungu Xia, Hanmin Huang

Index: J. Am. Chem. Soc. 134 , 9902, (2012)

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Abstract

A new strategy for generating benzylpalladium reactive species from toluenes via nondirected C(sp(3))-H activation has been developed. This led to construction of an efficient Pd-catalyzed reaction protocol for the oxidative carboxylation of benzylic C-H bonds to form substituted 2-phenylacetic acid esters and derivatives from inexpensive, commercially available starting materials.