Journal of Medicinal Chemistry 2006-06-15

Application of a mathematical topological pattern of antihistaminic activity for the selection of new drug candidates and pharmacology assays.

María J Duart, Ramón García-Domenech, Jorge Galvez, Pedro A Aleman, Rafael V Martín-Algarra, Gerardo M Antón-Fos

Index: J. Med. Chem. 49(12) , 3667-73, (2006)

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Abstract

Molecular topology was used to achieve a mathematical model capable of classifying compounds according to their antihistaminic activity and low sedative effects. By application of this model of activity to databases containing chemical reagents and drugs exhibiting other pharmacological activity, we selected 30 compounds with possible antihistaminic activity. After those with possible sedative effects were discarded, activity tests were performed with five chemical reagents and three drugs searching for in vivo antihistaminic activity. The obtained results indicate that compounds such as 4-[(E)-2-(1,3-benzothiazol-2-yl)vinyl]-N,N-dimethylaniline (AH2), 2-ethyl-9,10-dimethoxyanthracene (AH4), and 2,4-bis(alpha,alpha-dimethylbenzyl)phenol (AH5) showed antihistaminic activity above terfenadine, the reference drug, whereas others, for instance, pergolide, miconazole, trihexyphenidyl, 2-(dibenzylamino-3-phenyl-1-propanol (AH1), and N-benzylquininium chloride (AH3), were less active than terfenadine.