Organic & Biomolecular Chemistry 2005-10-07

Lactone-free ginkgolides via regioselective DIBAL-H reduction.

Hideki Ishii, Sergei V Dzyuba, Koji Nakanishi

Index: Org. Biomol. Chem. 3(19) , 3471-2, (2005)

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Abstract

The lactone rings of ginkgolide A are converted into corresponding tetrahydrofuran moieties via DIBAL-H reduction followed by deoxygenation of the formed lactols with Et3SiH-BF3.Et2O to produce a series of lactone-free ginkgolides.