Research communications in chemical pathology and pharmacology 1985-01-01

Evaluation of two distinctive beta-carbolines on serotonin binding in human platelets.

D L Taylor, W Tansey, J M Cook, B T Ho

Index: Res. Commun. Chem. Pathol. Pharmacol. 47(1) , 133-6, (1985)

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Abstract

6-MeOTHBC binds to both high and low affinity receptors in human platelets. The beta-carboline is less active than chlorimipramine at the low affinity site, and it is weaker than methysergide, a known 5-HT antagonist, at the high affinity site. The other beta-carboline, B-CCE, is not active at either receptor in platelets. The data supports the view that platelets could be used as a limited model for studying 5-HT-ergic neurons.