European Journal of Medicinal Chemistry 2015-03-06

Antileishmanial activity of quinazoline derivatives: synthesis, docking screens, molecular dynamic simulations and electrochemical studies.

Cesar Mendoza-Martínez, Norma Galindo-Sevilla, José Correa-Basurto, Victor Manuel Ugalde-Saldivar, Rosa Georgina Rodríguez-Delgado, Jessica Hernández-Pineda, Cecilia Padierna-Mota, Marcos Flores-Alamo, Francisco Hernández-Luis

Index: Eur. J. Med. Chem. 92C , 314-331, (2014)

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Abstract

A series of quinazoline-2,4,6-triamine were synthesized and evaluated in vitro against Leishmania mexicana. Among them, N(6)-(ferrocenmethyl)quinazolin-2,4,6-triamine (H2) showed activity on promastigotes and intracellular amastigotes, as well as low cytotoxicity in mammalian cells. Docking and electrochemical studies showed the importance of both the ferrocene and the heterocyclic nucleus to the observed activity. H2 is readily oxidized electrochemically, indicating that the mechanism of action probably involves redox reactions. Copyright © 2014 Elsevier Masson SAS. All rights reserved.