Journal of Antibiotics 1999-08-01

Production of 6-deoxy-13-cyclopropyl-erythromycin B by Saccharopolyspora erythraea NRRL 18643.

M S Brown, J P Dirlam, H A McArthur, E L McCormick, B K Morse, P A Murphy, T N O'Connell, M Pacey, D M Rescek, J Ruddock, R G Wax

Index: J. Antibiot. 52(8) , 742-7, (1999)

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Abstract

Cyclopropane carboxylic acid was fed to Saccharopolyspora erythraea NRRL 18643 (6-deoxyerythromycin producer), resulting in the production of 6-deoxy-13-cyclopropyl-erythromycin B. These studies provide further evidence that deoxyerythronolide B synthase has a relaxed specificity for the starter unit.