Journal of Antibiotics 1990-05-01

Chemical modification of erythromycins. IV. Synthesis and biological properties of 6-O-methylerythromycin B.

S Morimoto, T Adachi, Y Misawa, T Nagate, Y Watanabe, S Omura

Index: J. Antibiot. 43(5) , 544-9, (1990)

Full Text: HTML

Abstract

6-O-Methylerythromycin B has been synthesized from erythromycin B via regioselective methylation of the 6-hydroxyl group in 71% overall yield. This compound shows in vitro antibacterial activity comparable to erythromycins A and B and exhibits superior in vivo activity with improved pharmacokinetic properties.