Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) 1998-01-01

[Nitazole--an antimicrobial substance].

N F Kalinichenko

Index: Mikrobiol. Z. 60(1) , 83-91, (1998)

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Abstract

The antibacterial activity of protistocide drug nitazole has been revealed for the first time in the 80's at the Laboratory of Clinical Microbiology of the Mechnikov Research Institute of Microbiology and Immunology. Unlike other imidazoles, such as metronidazole and tinidazole, nitazole acts as the inhibitor of growth of gram-positive facultative and obligate anaerobic microorganisms as well as gram-negatives except for Pseudomonas aeruginosa and Proteus. Nitazole, as a main antimicrobial agent of many multicomponent drugs which are created on the hydrophilic basis (matrices), is particularly useful for topical treatment of wounds and burns in the first and second phases of these processes. Drugs which include nitazole possess not only antibacterial and protistocide activity but also act as anti-inflammatory, wound-healing ones and have osmotic property. These drugs are approved by the Ukrainian Ministry of Public Health for wide use in surgical, gynecological, proctological and dermatological clinics as well as in combustology.