The Journal of Organic Chemistry

Mono-and bisdiazotization of proflavine

W Firth III, LW Yielding

Index: Firth, William; Yielding, Lerena W. Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 3002 - 3004

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Citation Number: 5

Abstract

In the course of developing photoaffinity probes of biologically active compounds, we undertook the synthesis of the monoazido analogue, 4, of proflavine (1) by selective diazotization and appropriate substitution of the diazonium salt. An early claim'to the preparation of the monodiazonium salt 2 and its subsequent reduction in ethanol to yield 3- aminoacridine (6) has been disputed. 2 Other workers have prepared the monodiazonium ...