Life Sciences 1993-01-01

Geranylgeranylacetone protects the heart via caveolae and caveolin-3

Yasuo M. Tsutsumi, Rie Tsutsumi, Yousuke T. Horikawa, Yoko Sakai, Eisuke Hamaguchi, Yoshihiro Ishikawa, Utako Yokoyama, Asuka Kasai, Noriko Kambe, Katsuya Tanaka

Index: Life Sci. 101(1-2) , 43-8, (2014)

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Abstract

Aims Geranylgeranylacetone (GGA) is commonly utilized to protect the gastric mucosa in peptic ulcer disease. Recently GGA has been shown to protect the myocardium from ischemia/reperfusion by activating heat shock proteins. However, the exact mechanism as to how GGA activates these protective proteins is unknown. Caveolae and caveolin-3 (Cav-3) have been implicated in ischemia, anesthetic, and opioid induced cardiac protection. Given the lipophilic nature of GGA it is our hypothesis that GGA induced cardiac protection requires caveolae and Cav-3.