Bioorganic & medicinal chemistry letters

Discovery of selective metal-binding peptoids using 19 F encoded combinatorial libraries

MC Pirrung, K Park

Index: Pirrung, Michael C.; Park, Kaapjoo Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 18 p. 2115 - 2118

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Citation Number: 15

Abstract

A method for encoding solid-phase split/mix combinatorial libraries using the chemical shift of synthetic fluoroarenes ('F-codes') has been developed. They have wide chemical shift dispersion and are detectable at the sub-μmol level. 19F NMR is used for decoding. Nine fluoroarenes bearing linkers for attachment to solid-phase synthesis supports through a photocleavable group were prepared. A library of 90 N-alkylglycines bearing substituted ...