International Journal of Peptide and Protein Reseach 1993-10-01

Allyl-based groups for side-chain protection of amino-acids.

A Loffet, H X Zhang

Index: Int. J. Pept. Protein Res. 42 , 346, (1993)

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Abstract

Allyl and allyloxycarbonyl groups are used for the side-chain protection of amino acids. The protecting groups may be selectively cleaved using the reagent HSnBu3 under palladium catalysis. The preparation of Boc and Fmoc series of protected amino acids is described.