Biochemical and Biophysical Research Communications 2013-10-25

Cell recognition molecule L1 promotes embryonic stem cell differentiation through the regulation of cell surface glycosylation

Ying Li, Xiaohua Huang, Yue An, Feng Ren, Zara Zhuyun Yang, Hongmei Zhu, Lei Zhou, Xiaowen He, Melitta Schachner, Zhicheng Xiao, Keli Ma, Yali Li

Index: Biochem. Biophys. Res. Commun. 440(3) , 405-12, (2013)

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Abstract

• Down-regulating FUT9 and ST3Gal4 expression blocks L1-induced neuronal differentiation of ESCs. • Up-regulating FUT9 and ST3Gal4 expression in L1-ESCs depends on the activation of PLCγ. • L1 promotes ESCs to differentiate into neuron through regulating cell surface glycosylation.