Expert Opinion on Drug Safety 2010-07-01

Safety evaluation of zotepine for the treatment of schizophrenia.

Michael Riedel, Richard Musil, Florian Seemüller, Ilja Spellmann, Hans-Jürgen Möller, Rebecca Schennach-Wolff

Index: Expert Opin. Drug Saf. 9(4) , 659-66, (2010)

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Abstract

Atypical antipsychotics have become the first-line treatment for patients suffering from schizophrenia in the industrialized world. Given the frequent necessity of a life-long enduring antipsychotic treatment, the compounds' safety profile is of great importance for patients and caregivers. Zotepine is an antipsychotic with atypical properties and previous data have suggested a very favorable side effect profile.The aim of this review is to provide a broad knowledge base on the safety profile of zotepine deriving from currently available research results published in English medical databases. The focus of this research reports starts in the 1990s with zotepine's approval in Europe.This paper incorporates data on placebo-controlled studies of zotepine as well as studies with comparator compounds also beyond the diagnostic boarder of schizophrenia regarding zotepine's safety.The take home message of this safety evaluation of zotepine is that compared to typical compounds zotepine induces less extrapyramidal side effects; however, in terms of comparing zotepine's safety with other atypical antipsychotics more studies are needed to draw final conclusions.