Discovery and optimization of N-(3-(1, 3-dioxo-2, 3-dihydro-1H-pyrrolo [3, 4-c] pyridin-4-yloxy) phenyl) benzenesulfonamides as novel GPR119 agonists

M Yu, JK Zhang, Y Wang, J Zhu, F Kayser…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 1 p. 156 - 160

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Citation Number: 2

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... a Department of Medicinal Chemistry, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA; ... Therefore, the chemical feature of R 1 = –Me and R 2 = – i Pr as in 11 was adopted for subsequent studies. ...